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Histamine is a biologically active substance that potentiates the inflammatory and immune responses of the body, regulates physiological function in the gut, and acts as a neurotransmitter. Drugs that antagonize these effects by blocking or inhibiting histamine receptors H receptors are called antihistamines.
Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier. This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.
RDM first noticed the relevant differences in reporting rates, did the initial analyses, wrote the first draft of the paper, and is the guarantor. GP was responsible for the data processing assisted by Gillian Pearce.
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